Antibodies against citrulined vimentin

-

Anti-citrullinating anti-Saq / anti-MCV antibodies are representative of a wider family of anti-citrullinated protein / peptide autoantibodies (ACPAs). Cytrulinated vimentin is one of the eliminated (citrullinated) autoantigens of the synovial membrane, considered in the consideration of the pathogenesis of rheumatoid arthritis (RA). According to some authors, autoantibodies against citrulline-positive VMS are a promising serological markers for RA, although they have not been found in routine diagnostics. The first and so far the only Polish study on the utility of anti-Sa autoantibodies in the diagnosis of RA did not show any diagnostic benefit from the anti-Sa anti-Sa quantitative evaluation in addition to routine anti-CCP autoantibodies. The diagnostic sensitivity of anti-Sa in the diagnosis of RA was 36.6%, and the diagnostic specificity was 96.9%. Anti-Sa and anti-CCP co-occurrence was reported in 36.6% of RA patients and no isolated case of anti-Sa was demonstrated. According to the cited work, positive anti-Sa effects should be expected especially in those with RA who have high levels of anti-CCP. According to foreign data - showing a large ethnic diversity - the sensitivity of anti-Sa auto antibodies varies between 31-44%, with a specificity of 92-98%. According to some researchers, the presence of anti-Sa / anti-MCV autoantibodies is associated with a more severe course of RA and greater destruction of joints and the level of this marker correlates with disease activity and response to selected drugs. Other researchers do not share the opinion about the diagnostic or prognostic utility of anti-Sa / anti-MCV autoantibodies. Because of the ethnic differences in the distribution and clinical utility of autoantibodies, it is worthwhile to rely on local coverage data. Laboratory assessment

Antibodies to citrulline vimentin are usually quantified in serum by immunoassay. Antibodies that capture autoantibodies from the test sample may be citrulline vimentin (so-called antigen Sa) or mutant citrullinated vimentin (MCV). Therefore, this marker - depending on the analytical method used - is referred to as anti-Sa or anti-MCV. Please note that the results obtained with different diagnostic tests show some degree of differentiation. Bibliography

wiki

Comments

Post a Comment

Popular posts from this blog

Pupo Román

-
José René "Pupo" Román Fernández (died 1961) - Dominican general. Curriculum vitae In the Dominican history, when the dictatorial president Rafael Leónidas Trujillo was in power, Roman was his niece's husband and "third person in the state" (Trujillo and SIM Arturo Espaillata). He was the Minister of Armed Forces, a close associate of Trujillo, which did not prevent him from accepting Trujillo's murder in 1961 from the American consul in the Dominican Republic, Henry Dearborn. He led to the murder of Rafael Trujillo on May 30, 1961, but he could not use this to overthrow his followers. He failed to arrest them along with Trujillo's sons such as Ramfis. Ultimately, the conspiracy ended with the conspirators' defeat when Zacarias - chauffeur Trujillo - survived the presidential bombardment and handed over the drafts of the bombers and Arturo Espaillat informed Roman about the death of the commander - at the sight of Arturo Espaillata Roman revealed ...
Read more

Myrmex Indikos

-
Myrmex Indikos, pol. Indian ant - an alleged species of gigantic ants (according to Herodot's description, larger than foxes, but smaller than dogs). The earliest mention of these creatures is dated to the fifth century BC, and its author is Herodotus. According to her, these ants inhabited the deserts of Persia and India and extracted gold from their sands. Several such creatures were kept in the residence of the King of Persia. Gold was to be obtained by caravans made up of several camels in the heat of the day, when the ants were protected underground. You had to do it quickly, because the ants sensed the smell of people and went on the pursuit, and they were deadly dangerous. This story is confirmed by the next accounts: Nearchos, one of the army officers of Alexander Macedoński, and Megastenes - a historian and traveler. The fragment of the Megasthenes (IV-III century BC) preserved in fragments can be seen in the underground mines at the foot of the mountains on the easte...
Read more

Names of streets and squares

-
The names of the streets and squares were originally of a topographical nature, that is, they informed about: Researchers propose two names for these toponyms - urban or plateonimy. S. Urbańczyk points out that the older names were spontaneously formed and sprouted in the daily lives of the inhabitants of the place. The information contained herein was related to the characteristics of the place (eg appearance), important road directions (geographic orientation) or values, functions and economic meanings called places / objects in the settlement for the inhabitants' lives. Former names are protected by law, but are often not respected by managers of the municipality, county or province. Currently the names of streets and squares are given by the commune authorities, county governors or voivodships. There is a tendency to use commemorative names, ie to commemorate deserving people and important events (eg Zygmunt August Street, 3. Maja Street). The names of the districts are ...
Read more