Antivitamin K

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Antivitamin K - a chemical compound that exhibits an antagonistic effect on vitamin K, blocking the vitamin K cycle. competitive inhibitor

The anti-K drugs include:

There are two drugs available in Poland: warfarin and acenocoumarol.

Mechanism of action

Antivitamin K is a cofactor in post-translational carboxylation of glutamic acid residues to L-carboxyglutamic acid in N-terminal regions of vitamin K-dependent proteins (coagulation factors: II, VII, IX and X). This means that it inhibits the vitamin K- As a result, carboxylated and decarboxylated proteins with reduced procoagulant activity are produced in the liver. Course of treatment

The effect of antititin K treatment, it is an anticoagulant effect, occurs after 2-7 days. Treatment should be accompanied by frequent INR and appropriate diet. Accepted doses depend on individual characteristics as well as on age, liver disease, bleeding risk and the presence of specific factors such as pregnancy. Application

Antivitamin K is used to treat atrial fibrillation or flutter; People over 75 years of age with hypertension, diabetes, left ventricular systolic dysfunction and symptomatic heart failure; Patients with artificial valve prostheses, rheumatoid arthritis, post-myocardial infarction or arterial embolism, and thrombosis in the heart cavities. Contraindications Bibliography

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