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Slit connection
Neksus, a fissure connection (Latin: macula communicans) is a type of intercellular connection that consists of a hydrophilic channel and a narrow intercellular gap with a width of 2-4 nm. This channel consists of six protein subunits - connexins, which form a hexagonal ring system (the so-called connecon). One slotted connection consists of two connexons (half-channels) that come from two neighboring cells.
The channel may be in an open or closed state depending on the conformation of the connexins. The conformation is influenced by many factors, including potential difference between cells, membrane cell potential, pH, free Ca concentration. The diameter of the duct is about 1.4 nm and allows particles of up to 1000 Da and ions to move.
Nexus is found in most tissues in almost all animals (it is not found in the most primitive ones like sponges). Innexines are found in invertebrates instead of connexins. Similar functions in plant cells are fulfilled by plasmods.
In nerve cells, slit connections form electrical synapses. Bibliography
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