Norepinephrine and dopamine dysinhibitors

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Norepinephrine and dopamine disinhibitors (NDDI) dysinhibitors - a group of drugs whose mechanism of action consists in the inhibition (disinhibition) of the release of noradrenaline neurotransmitters and dopamine in the prefrontal cortex by antagonism against 5HT2C serotoninergic receptors. This effect is attributed to antidepressants: agomelatine (also acting on melatoninergic receptors) and fluoxetine (whose main mechanism of action is the inhibition of serotonin reuptake). Flibanserin, a drug registered in the indication of desire disorders in premenopausal women, inhibits the release of norepinephrine and dopamine by acting on 5HT1A receptors.

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